Sig (directions)
Sig introduces the directions on a prescription: the words that go on the medicine’s label. It is short for the Latin signa, “mark” or “label it”.
How to read it
The American Heritage Dictionary gives Sig. three ways: Latin signa, “mark or label it”; signetur, “let it be marked or labeled”; and, in medicine, signature. The Minnesota Board of Pharmacy lists sig simply as “write on label”. It is the last of the traditional parts of a prescription, after the ℞ and the drugs: a 2012 study of prescriptions in Oman describes it as the part, usually preceded by the sign, where the directions to be written on the dispensed medicine go.
Also searched as: sig, sig meaning, sig medical abbreviation, signa.
These pages explain what medical abbreviations and symbols stand for. They are not medical advice and give no doses: a pharmacist or prescriber can explain what any label means for you.
The Sig line and the Latin shorthand
The layout was standardised in the nineteenth century, according to the historian Robert Woods, with the final line of the prescription giving the patient’s directions, sometimes in English but commonly in abbreviated Latin. That line is where shorthand such as PO, BID and PRN appears, and it is the line that goes onto the label.
More prescription abbreviations
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Sources
- Sig. (American Heritage Dictionary entry), The American Heritage Dictionary of the English Language, Fifth Edition, HarperCollins Publishers, sig., abbr.
- Partial list of prescription abbreviations, Minnesota Board of Pharmacy, Partial list of prescription abbreviations, Minnesota Board of Pharmacy, sig
- Identifying errors in handwritten outpatient prescriptions in Oman, Journal of Young Pharmacists 2012;4(4):267–272 (Oman Medical College), Journal of Young Pharmacists, Introduction
- Dr Smellie’s prescriptions for pregnant women, Robert Woods, Medical History 2008;52(2):257–276, Cambridge University Press, Symbols and conventions
Last reviewed September 30, 2026 by Rory Hansen. How we research